AC   MF_01844;
DC   Protein; auto
TR   HAMAP; MF_01844; -; 1; level=0
XX
Names: NhaA
XX
ID   NHAA
DE   RecName: Full=Na(+)/H(+) antiporter NhaA;
DE   AltName: Full=Sodium/proton antiporter NhaA;
GN   Name=nhaA;
XX
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out);
CC         Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family.
XX
DR   Pfam; PF06965; Na_H_antiport_1; 1; trigger=no
DR   NCBIfam; TIGR00773; NhaA; 1; trigger=no
case not <OC:Escherichia> and not <OC:Shigella>
DR   General; Transmembrane; -; 9-12; trigger=yes
end case
XX
KW   Antiport
KW   Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Ion transport
KW   Membrane
KW   Sodium
KW   Sodium transport
KW   Transmembrane
KW   Transport
KW   Transmembrane helix
XX
GO   GO:0015297; F:antiporter activity
GO   GO:0015081; F:sodium ion transmembrane transporter activity
GO   GO:0006814; P:sodium ion transport
GO   GO:0005886; C:plasma membrane
XX
FT   From: NHAA_ECOLI (P13738)
case <OC:Escherichia> or <OC:Shigella>
FT   TOPO_DOM        Nter..11
FT                   /note="Cytoplasmic"
FT   TRANSMEM        12..31
FT                   /note="Helical; Name=1"
FT   TOPO_DOM        32..58
FT                   /note="Periplasmic"
FT   TRANSMEM        59..80
FT                   /note="Helical; Name=2"
FT   TOPO_DOM        81..96
FT                   /note="Cytoplasmic"
FT   TRANSMEM        97..116
FT                   /note="Helical; Name=3"
FT   TOPO_DOM        117..122
FT                   /note="Periplasmic"
FT   TRANSMEM        123..130
FT                   /note="Helical; Name=4"
FT   TOPO_DOM        131..154
FT                   /note="Cytoplasmic"
FT   TRANSMEM        155..176
FT                   /note="Helical; Name=5"
FT   TOPO_DOM        177..180
FT                   /note="Periplasmic"
FT   TRANSMEM        181..200
FT                   /note="Helical; Name=6"
FT   TOPO_DOM        201..204
FT                   /note="Cytoplasmic"
FT   TRANSMEM        205..222
FT                   /note="Helical; Name=7"
FT   TOPO_DOM        223
FT                   /note="Periplasmic"
FT   TRANSMEM        224..236
FT                   /note="Helical; Name=8"
FT   TOPO_DOM        237..253
FT                   /note="Cytoplasmic"
FT   TRANSMEM        254..272
FT                   /note="Helical; Name=9"
FT   TOPO_DOM        273..286
FT                   /note="Periplasmic"
FT   TRANSMEM        287..310
FT                   /note="Helical; Name=10"
FT   TOPO_DOM        311..339
FT                   /note="Cytoplasmic"
FT   TRANSMEM        340..350
FT                   /note="Helical; Name=11"
FT   TOPO_DOM        351..357
FT                   /note="Periplasmic"
FT   TRANSMEM        358..380
FT                   /note="Helical; Name=12"
FT   TOPO_DOM        381..Cter
FT                   /note="Cytoplasmic"
end case
XX
Size: 376-503;
Related: None;
Template: P13738; O85187; Q56725;
Scope:
 Bacteria
Fusion:
 Nter: <Unknown>; <Thioredoxin domain>
 Cter: <Thioredoxin domain>; <Peptidase S49>
Duplicate: in ACICJ, ALIB4, CAMFF, CAMHC, CAMJ8, CAMJD, CAMJE, CAMJJ, CAMJR,
 CLAM3, CLOB8, DEIGD, ERYLH, FLAJ1, FRAAA, HELHP, KINRD, KLEP7, MAGMM, MYCGI,
 MYCSJ, MYCSK, MYCSS, MYCVP, MYXXD, NOCSJ, NOVAD, BRUA4, SYNC1, PELPD, PSE14,
 PSEA6, PSEP1, PSEPK, PSESM, PSEU2, PSYIN, RHOJR, SACD2, SACEN, SALAI, SALTO,
 SHEDO, SORC5, STRCO, VIBVU
Plasmid: in ACICJ, DEIGD, KLEP7, NITHX, RHIME
Comments: Some of the Rickettsiales are shorter than orthologs; sequences
 are not shown in alignment and not taken into account in size range.
XX
# Revision 1.26 2023/06/01
//