AC   MF_01846;
DC   Protein; auto
TR   HAMAP; MF_01846; -; 1; level=0
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Names: Nudix_NudI
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ID   NUDI
DE   RecName: Full=Nucleoside triphosphatase NudI;
DE            EC=3.6.1.9;
DE   AltName: Full=Nucleotide diphosphatase NudI;
DE   AltName: Full=dCTP diphosphatase;
DE            EC=3.6.1.12;
DE   AltName: Full=dTTP diphosphatase;
DE            EC=3.6.1.-;
DE   AltName: Full=dUTP diphosphatase;
DE            EC=3.6.1.23;
DE   AltName: Full=Pyrimidine deoxynucleoside triphosphate diphosphatase;
GN   Name=nudI;
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CC   -!- FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates, with a
CC       preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and
CC       dCTP).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-
CC         phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside 5'-phosphate + diphosphate + H(+);
CC         Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTTP + H2O = diphosphate + dTMP + H(+); Xref=Rhea:RHEA:28534,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:37568, ChEBI:CHEBI:63528;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dCTP + H2O = dCMP + diphosphate + H(+); Xref=Rhea:RHEA:22636,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57566, ChEBI:CHEBI:61481; EC=3.6.1.12;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. NudI subfamily.
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DR   Pfam; PF00293; NUDIX; 1; trigger=no
DR   PRINTS; PR00502; NUDIXFAMILY; 1; trigger=no
DR   PROSITE; PS51462; NUDIX; 1; trigger=yes
DR   PROSITE; PS00893; NUDIX_BOX; 1; trigger=no
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KW   Hydrolase
KW   Magnesium
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GO   GO:0047429; F:nucleoside triphosphate diphosphatase activity
GO   GO:0000287; F:magnesium ion binding
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FT   From: NUDI_ECOLI (P52006)
FT   MOTIF           38..59
FT                   /note="Nudix box"
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Size: 140-141;
Related: None;
Template: P52006;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.16 2022/06/29
//