AC   MF_01858;
DC   Protein; auto
TR   HAMAP; MF_01858; -; 1; level=0
XX
Names: 23SrRNA_methyltr_KL
XX
ID   RLMKL
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase K/L;
DE   Includes:
DE     RecName: Full=23S rRNA m2G2445 methyltransferase;
DE              EC=2.1.1.173;
DE     AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL;
DE   Includes:
DE     RecName: Full=23S rRNA m7G2069 methyltransferase;
DE              EC=2.1.1.264;
DE     AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK;
GN   Name=rlmL;
XX
CC   -!- FUNCTION: Specifically methylates the guanine in position 2445
CC       (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) +
CC         N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42740, Rhea:RHEA-COMP:10215, Rhea:RHEA-COMP:10216,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.173;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) +
CC         N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43772, Rhea:RHEA-COMP:10688, Rhea:RHEA-COMP:10689,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.264;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmKL family.
XX
DR   PROSITE; PS51165; THUMP; 1; trigger=yes
DR   PROSITE; PS01261; UPF0020; 1; trigger=no
DR   Pfam; PF03602; Cons_hypoth95; 0-1; trigger=no
DR   Pfam; PF02926; THUMP; 1; trigger=no
DR   Pfam; PF01170; UPF0020; 1; trigger=no
DR   PIRSF; PIRSF037618; RNA_Mtase_bacteria_prd; 1; trigger=no
XX
KW   Cytoplasm
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0052915; F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity
GO   GO:0070043; F:rRNA (guanine-N7-)-methyltransferase activity
GO   GO:0031167; P:rRNA methylation
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 676-807;
Related: None;
Template: P75864;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2019/11/19
//