AC   MF_01875;
DC   Protein; auto
TR   HAMAP; MF_01875; -; 1; level=0
XX
Names: Prokaryotic_Ku
XX
ID   KU
DE   RecName: Full=Non-homologous end joining protein Ku;
GN   Name=ku;
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CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family.
XX
DR   Pfam; PF02735; Ku; 1; trigger=yes
DR   NCBIfam; TIGR02772; Ku_bact; 1; trigger=no
DR   PIRSF; PIRSF006493; Prok_Ku; 1; trigger=no
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KW   DNA damage
KW   DNA recombination
KW   DNA repair
KW   DNA-binding
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GO   GO:0006281; P:DNA repair
GO   GO:0006974; P:DNA damage response
GO   GO:0006303; P:double-strand break repair via nonhomologous end joining
GO   GO:0003690; F:double-stranded DNA binding
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FT   None
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Size: 223-422;
Related: None;
Template: O34859; P9WKD9; A0R3S7; Q9I1W5;
Scope:
 Bacteria
 Archaea; Euryarchaeota
Fusion:
 Nter: None
 Cter: None
Duplicate: in GEOUR, SACEN
Plasmid: in ALLAM
Comments: LigD, the NHEJ partner of Ku, is a multifunctional protein
 composed of 2-3 domains; polymerase/primase, phosphoesterase and ligase
 domains. Domain order in LigD is permutated in Actinomycetota and
 Gammaproteobacteria, whereas the 3 domains are encoded as separate
 proteins in at least one Euryarchaeota. In Bacilli LigD only has the
 polymerase/primase and ligase domains.
XX
# Revision 1.12 2023/11/28
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