AC MF_01886; DC Protein; auto TR HAMAP; MF_01886; -; 1; level=0 XX Names: tRNA_acetyltr_TmcA XX ID TMCA DE RecName: Full=tRNA(Met) cytidine acetyltransferase TmcA; DE EC=2.3.1.193; GN Name=tmcA; XX CC -!- FUNCTION: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at CC the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl CC donor and ATP (or GTP). CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = CC ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + CC phosphate; Xref=Rhea:RHEA:43788, Rhea:RHEA-COMP:10693, Rhea:RHEA- CC COMP:10694, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, CC ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; CC EC=2.3.1.193; CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the TmcA family. XX DR PROSITE; PS51186; GNAT; 1; trigger=yes DR Pfam; PF08351; DUF1726; 1; trigger=no DR Pfam; PF05127; DUF699; 1; trigger=no DR Pfam; PF00583; Acetyltransf_1; 1; trigger=no XX KW Acyltransferase KW ATP-binding KW Cytoplasm KW Nucleotide-binding KW RNA-binding KW Transferase KW tRNA processing KW tRNA-binding XX GO GO:0005524; F:ATP binding GO GO:0000049; F:tRNA binding GO GO:0051392; F:tRNA N-acetyltransferase activity GO GO:0051391; P:tRNA acetylation GO GO:0002101; P:tRNA wobble cytosine modification GO GO:0005737; C:cytoplasm XX FT From: TMCA_ECOLI (P76562) FT BINDING 174..175 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: G-A FT BINDING 202..211 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: G-R-G-K-S-A-L-A-G-Q FT BINDING 461..463 FT /ligand="acetyl-CoA" FT /ligand_id="ChEBI:CHEBI:57288" FT Optional; Condition: [IV]-A-[VT] FT BINDING 468..474 FT /ligand="acetyl-CoA" FT /ligand_id="ChEBI:CHEBI:57288" FT Optional; Condition: Q-R-E-G-T-G-R FT BINDING 180 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: Q FT BINDING 319 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: R FT BINDING 499 FT /ligand="acetyl-CoA" FT /ligand_id="ChEBI:CHEBI:57288" FT Optional; Condition: E FT BINDING 506 FT /ligand="acetyl-CoA" FT /ligand_id="ChEBI:CHEBI:57288" FT Optional; Condition: R XX Size: 596-868; Related: None; Template: P76562; D4GW73; Scope: Bacteria; Gammaproteobacteria Archaea Fusion: Nter: None Cter: None Duplicate: in ACTPJ, AERPE, HYPBU, IGNH4, METS5, SULAC, SULIA, SULID, SULIK, SULIL, SULIM, SULIN, SULIY, SULS9, SACS2, SULTO Plasmid: None Comments: None XX # Revision 1.12 2022/11/19 //