AC   MF_01891;
DC   Protein; auto
TR   HAMAP; MF_01891; -; 1; level=0
XX
Names: FhlC
XX
ID   FLHC
DE   RecName: Full=Flagellar transcriptional regulator FlhC;
GN   Name=flhC;
XX
CC   -!- FUNCTION: Functions in complex with FlhD as a master transcriptional
CC       regulator that regulates transcription of several flagellar and non-
CC       flagellar operons by binding to their promoter region. Activates
CC       expression of class 2 flagellar genes, including fliA, which is a
CC       flagellum-specific sigma factor that turns on the class 3 genes. Also
CC       regulates genes whose products function in a variety of physiological
CC       pathways.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBUNIT: Heterohexamer composed of two FlhC and four FlhD subunits.
CC       Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer
CC       assembles by dimerization of two heterotrimers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the FlhC family.
XX
DR   Pfam; PF05280; FlhC; 1; trigger=no
DR   PIRSF; PIRSF003159; FlhC; 1; trigger=no
XX
KW   Activator
KW   Bacterial flagellum biogenesis
KW   Cytoplasm
KW   DNA-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
KW   Transcription
KW   Transcription regulation
XX
GO   GO:0003677; F:DNA binding
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:1902208; P:regulation of bacterial-type flagellum assembly
GO   GO:0005737; C:cytoplasm
XX
FT   From: FLHC_ECOLI (P0ABY7)
FT   BINDING         137
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         160
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 169-225;
Related: None;
Template: P0ABY7;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in PARP8
Comments: None
XX
# Revision 1.12 2023/01/26
//