AC   MF_01909;
DC   Protein; auto
TR   HAMAP; MF_01909; -; 1; level=0
XX
Names: TFE_arch
XX
ID   TFE
DE   RecName: Full=Transcription factor E;
DE            Short=TFE;
DE   AltName: Full=TFIIE subunit alpha homolog;
DE   AltName: Full=Transcription initiation factor TFIIE;
GN   Name=tfe;
XX
CC   -!- FUNCTION: Transcription factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Facilitates transcription
CC       initiation by enhancing TATA-box recognition by TATA-box-binding
CC       protein (Tbp), and transcription factor B (Tfb) and RNA polymerase
CC       recruitment. Not absolutely required for transcription in vitro, but
CC       particularly important in cases where Tbp or Tfb function is not
CC       optimal. It dynamically alters the nucleic acid-binding properties of
CC       RNA polymerases by stabilizing the initiation complex and destabilizing
CC       elongation complexes. Seems to translocate with the RNA polymerase
CC       following initiation and acts by binding to the non template strand of
CC       the transcription bubble in elongation complexes.
CC   -!- SUBUNIT: Monomer. Interaction with RNA polymerase subunits RpoF and
CC       RpoE is necessary for Tfe stimulatory transcription activity. Able to
CC       interact with Tbp and RNA polymerase in the absence of DNA promoter.
CC       Interacts both with the preinitiation and elongation complexes.
CC   -!- DOMAIN: The winged helix domain is involved in binding to DNA in the
CC       preinitiation complex.
CC   -!- SIMILARITY: Belongs to the TFE family.
XX
DR   PROSITE; PS51344; HTH_TFE_IIE; 1; trigger=yes
DR   Pfam; PF02002; TFIIE_alpha; 1; trigger=no
DR   NCBIfam; TIGR00373; TIGR00373; 1; trigger=no
XX
KW   DNA-binding
KW   Transcription
KW   Transcription regulation
XX
GO   GO:0006352; P:DNA-templated transcription initiation
XX
FT   None
XX
Size: 139-211;
Related: None;
Template: Q980M5; Q8U3H5; O27705; Q58187;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.16 2023/06/01
//