AC   MF_01913;
DC   Protein; auto
TR   HAMAP; MF_01913; -; 1; level=0
XX
Names: SLA_reductase
XX
ID   SQUU
DE   RecName: Full=3-sulfolactaldehyde reductase;
DE            Short=SLA reductase;
DE            EC=1.1.1.373;
XX
CC   -!- FUNCTION: Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-
CC       sulfonate (DHPS).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S)-3-sulfopropanediol + NAD(+) = (2S)-3-sulfolactaldehyde +
CC         H(+) + NADH; Xref=Rhea:RHEA:40511, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90109,
CC         ChEBI:CHEBI:176527; EC=1.1.1.373;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:40513;
CC   -!- SIMILARITY: Belongs to the HIBADH-related family. 3-sulfolactaldehyde
CC       reductase subfamily.
XX
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1; trigger=no
DR   Pfam; PF03446; NAD_binding_2; 1; trigger=no
DR   PIRSF; PIRSF000103; HIBADH; 1; trigger=no
XX
KW   NAD
KW   Oxidoreductase
XX
GO   GO:0061596; F:3-sulfolactaldehyde reductase activity
GO   GO:1902777; P:6-sulfoquinovose(1-) catabolic process
XX
FT   From: SQUU_ECOLI (P0A9V8)
FT   BINDING         11..12
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q-M
FT   BINDING         174..178
FT                   /ligand="2,3-dihydroxypropane-1-sulfonate"
FT                   /ligand_id="ChEBI:CHEBI:77138"
FT   Condition: N-N-Y-M-S
FT   ACT_SITE        171
FT   Condition: K
FT   BINDING         31
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: D
FT   BINDING         65
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: L
FT   BINDING         96
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: T
FT   BINDING         123
FT                   /ligand="2,3-dihydroxypropane-1-sulfonate"
FT                   /ligand_id="ChEBI:CHEBI:77138"
FT   Condition: R
FT   BINDING         240
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: K
XX
Size: 280-320;
Related: None;
Template: P0A9V8;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2022/11/19
//