AC   MF_01916;
DC   Protein; auto
TR   HAMAP; MF_01916; -; 1; level=0
XX
Names: Cardiolipin_synth_Cls
XX
ID   CLS
DE   RecName: Full=Cardiolipin synthase;
DE            Short=CL synthase;
DE            EC=2.7.8.-;
XX
CC   -!- FUNCTION: Catalyzes the reversible phosphatidyl group transfer from one
CC       phosphatidylglycerol molecule to another to form cardiolipin (CL)
CC       (diphosphatidylglycerol) and glycerol.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a
CC         cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily.
XX
DR   PROSITE; PS50035; PLD; 2; trigger=yes
DR   Pfam; PF13091; PLDc_2; 0-2; trigger=no
DR   Pfam; PF13396; PLDc_N; 0-1; trigger=no
DR   Pfam; PF00614; PLDc; 0-2; trigger=no
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1; trigger=no
DR   General; Transmembrane; -; 2-3; trigger=yes
XX
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: CLSA_BACSU (P71040)
FT   ACT_SITE        222
FT   Condition: H
FT   ACT_SITE        224
FT   Condition: K
FT   ACT_SITE        229
FT   Condition: D
FT   ACT_SITE        400
FT   Condition: H
FT   ACT_SITE        402
FT   Condition: K
FT   ACT_SITE        407
FT   Condition: D
XX
Size: 440-550;
Related: None;
Template: P71040;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/06/01
//