AC   MF_01917;
DC   Protein; auto
TR   HAMAP; MF_01917; -; 1; level=0
XX
Names: Cardiolipin_synth_ClsB
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ID   CLSB
DE   RecName: Full=Cardiolipin synthase B;
DE            Short=CL synthase;
DE            EC=2.7.8.-;
GN   Name=clsB;
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CC   -!- FUNCTION: Catalyzes the phosphatidyl group transfer from one
CC       phosphatidylglycerol molecule to another to form cardiolipin (CL)
CC       (diphosphatidylglycerol) and glycerol.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a
CC         cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. Cardiolipin synthase
CC       subfamily. ClsB sub-subfamily.
XX
DR   PROSITE; PS50035; PLD; 2; trigger=yes
DR   Pfam; PF13091; PLDc_2; 2; trigger=no
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KW   Cell membrane
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Membrane
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   Transferase
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GO   GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   From: CLSB_ECOLI (P0AA84)
FT   ACT_SITE        113
FT   Condition: H
FT   ACT_SITE        115
FT   Condition: K
FT   ACT_SITE        120
FT   Condition: D
FT   ACT_SITE        290
FT   Condition: H
FT   ACT_SITE        292
FT   Condition: K
FT   ACT_SITE        297
FT   Condition: D
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Size: 370-460;
Related: None;
Template: P0AA84;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/01/26
//