AC   MF_01920;
DC   Protein; auto
TR   HAMAP; MF_01920; -; 1; level=0
XX
Names: Helicase_Rep
XX
ID   REP
DE   RecName: Full=ATP-dependent DNA helicase Rep;
DE            EC=5.6.2.4;
DE   AltName: Full=DNA 3'-5' helicase Rep;
GN   Name=rep;
XX
CC   -!- FUNCTION: Rep helicase is a single-stranded DNA-dependent ATPase
CC       involved in DNA replication; it can initiate unwinding at a nick in the
CC       DNA. It binds to the single-stranded DNA and acts in a progressive
CC       fashion along the DNA in the 3' to 5' direction.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
XX
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1; trigger=yes
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1; trigger=yes
DR   Pfam; PF00580; UvrD-helicase; 1; trigger=no
DR   Pfam; PF13361; UvrD_C; 1; trigger=no
DR   NCBIfam; TIGR01074; rep; 1; trigger=no
XX
KW   ATP-binding
KW   DNA replication
KW   DNA-binding
KW   Helicase
KW   Hydrolase
KW   Nucleotide-binding
KW   Isomerase
XX
GO   GO:0043138; F:3'-5' DNA helicase activity
GO   GO:0005524; F:ATP binding
GO   GO:0003697; F:single-stranded DNA binding
GO   GO:0006268; P:DNA unwinding involved in DNA replication
XX
FT   From: REP_ECOLI (P09980)
FT   BINDING         278
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: R
XX
Size: 640-750;
Related: None;
Template: P09980;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2023/11/13
//