AC   MF_01922;
DC   Protein; auto
TR   HAMAP; MF_01922; -; 1; level=0
XX
Names: TYW2_archaea
XX
ID   TYW2
DE   RecName: Full=tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase;
DE            EC=2.5.1.114;
DE   AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw2;
GN   Name=taw2;
XX
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a
CC       component of the wyosine derivatives biosynthesis pathway. Catalyzes
CC       the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-
CC       adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-
CC       aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of
CC       tRNA(Phe).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine =
CC         4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) +
CC         H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA-
CC         COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315,
CC         ChEBI:CHEBI:73550; EC=2.5.1.114;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM5/TYW2 family.
XX
DR   PROSITE; PS51684; SAM_MT_TRM5_TYW2; 1; trigger=no
DR   Pfam; PF02475; Met_10; 1; trigger=no
XX
KW   Cytoplasm
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
XX
GO   GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO   GO:0008033; P:tRNA processing
GO   GO:0005737; C:cytoplasm
XX
FT   From: TYW2_METJA (Q58952)
FT   BINDING         154..155
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [DE]-N
FT   BINDING         80
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [SA]
FT   BINDING         87
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [RK]
FT   BINDING         127
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
XX
Size: 240-442;
Related: None;
Template: Q58952; O58523;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/11/19
//