AC   MF_01927;
DC   Protein; auto
TR   HAMAP; MF_01927; -; 1; level=0
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Names: PurU
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ID   PURU
DE   RecName: Full=Formyltetrahydrofolate deformylase;
DE            EC=3.5.1.10;
DE   AltName: Full=Formyl-FH(4) hydrolase;
GN   Name=purU;
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CC   -!- FUNCTION: Catalyzes the hydrolysis of 10-formyltetrahydrofolate
CC       (formyl-FH4) to formate and tetrahydrofolate (FH4).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-
CC         tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366; EC=3.5.1.10;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
CC   -!- SIMILARITY: Belongs to the PurU family.
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DR   PROSITE; PS51671; ACT; 1; trigger=yes
DR   Pfam; PF01842; ACT; 1; trigger=no
DR   Pfam; PF00551; Formyl_trans_N; 1; trigger=no
DR   PRINTS; PR01575; FFH4HYDRLASE; 1; trigger=no
DR   NCBIfam; TIGR00655; PurU; 1; trigger=no
DR   PIRSF; PIRSF036480; FormyFH4_hydr; 1; trigger=no
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KW   Hydrolase
KW   One-carbon metabolism
KW   Purine biosynthesis
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GO   GO:0008864; F:formyltetrahydrofolate deformylase activity
GO   GO:0006189; P:'de novo' IMP biosynthetic process
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FT   From: PURU_ECOLI (P37051)
FT   ACT_SITE        225
FT   Condition: D
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Size: 230-340;
Related: None;
Template: P37051;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.6 2023/07/18
//