AC MF_01928; DC Protein; auto TR HAMAP; MF_01928; -; 1; level=0 XX Names: PurK XX ID PURK DE RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase; DE Short=N5-CAIR synthase; DE EC=6.3.4.18; DE AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase; GN Name=purK; XX CC -!- FUNCTION: Catalyzes the ATP-dependent conversion of 5-aminoimidazole CC ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole CC ribonucleotide (N5-CAIR). CC -!- CATALYTIC ACTIVITY: CC Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + CC hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + CC ADP + 2 H(+) + phosphate; Xref=Rhea:RHEA:19317, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58730, ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; CC EC=6.3.4.18; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5- CC amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- CC phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. CC -!- SUBUNIT: Homodimer. CC -!- SIMILARITY: Belongs to the PurK/PurT family. XX DR PROSITE; PS50975; ATP_GRASP; 1; trigger=no DR Pfam; PF02222; ATP-grasp; 1; trigger=no DR NCBIfam; TIGR01161; purK; 1; trigger=no XX KW ATP-binding KW Ligase KW Nucleotide-binding KW Purine biosynthesis XX GO GO:0034028; F:5-(carboxyamino)imidazole ribonucleotide synthase activity GO GO:0006189; P:'de novo' IMP biosynthetic process XX FT From: PURK_ECOLI (P09029) case FT DOMAIN 84..267 FT /note="ATP-grasp" end case FT BINDING 125..131 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: [GA]-Y-D-G-x-G-Q FT BINDING 153..156 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: [EQD]-x-x-[IVL] FT BINDING 237..238 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: N-E FT BINDING 80 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: [RK] FT BINDING 120 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: K FT BINDING 161 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: E FT BINDING 184 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT Optional; Condition: H XX Size: 335-460; Related: None; Template: P09029; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.8 2023/06/01 //