AC   MF_01929;
DC   Protein; auto
TR   HAMAP; MF_01929; -; 1; level=0
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Names: PurE_classI
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ID   PURE
DE   RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase;
DE            Short=N5-CAIR mutase;
DE            EC=5.4.99.18;
DE   AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase;
GN   Name=purE;
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CC   -!- FUNCTION: Catalyzes the conversion of N5-carboxyaminoimidazole
CC       ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide
CC       (CAIR).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-
CC         amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate;
CC         Xref=Rhea:RHEA:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:58730,
CC         ChEBI:CHEBI:77657; EC=5.4.99.18;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
CC   -!- SIMILARITY: Belongs to the AIR carboxylase family. Class I subfamily.
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DR   Pfam; PF00731; AIRC; 1; trigger=no
DR   NCBIfam; TIGR01162; purE; 1; trigger=no
DR   PIRSF; PIRSF001338; AIR_carboxylase; 1; trigger=no
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KW   Isomerase
KW   Purine biosynthesis
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GO   GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity
GO   GO:0006189; P:'de novo' IMP biosynthetic process
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FT   From: PURE_ECOLI (P0AG18)
FT   BINDING         16
FT                   /ligand="substrate"
FT   Condition: S
FT   BINDING         19
FT                   /ligand="substrate"
FT   Condition: D
FT   BINDING         46
FT                   /ligand="substrate"
FT   Condition: R
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Size: 157-339;
Related: None;
Template: P0AG18;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are
 mechanistically related but bind different substrates.
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# Revision 1.7 2023/06/01
//