AC MF_01930; DC Protein; auto TR HAMAP; MF_01930; -; 1; level=0 XX Names: PurN XX ID PUR3 DE RecName: Full=Phosphoribosylglycinamide formyltransferase; DE EC=2.1.2.2; DE AltName: Full=5'-phosphoribosylglycinamide transformylase; DE AltName: Full=GAR transformylase; DE Short=GART; GN Name=purN; XX CC -!- FUNCTION: Catalyzes the transfer of a formyl group from 10- CC formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), CC producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and CC tetrahydrofolate. CC -!- CATALYTIC ACTIVITY: CC Reaction=(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D- CC ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)- CC formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide; CC Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453, CC ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:195366; CC EC=2.1.2.2; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)- CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D- CC ribosyl)glycinamide (10-formyl THF route): step 1/1. CC -!- SIMILARITY: Belongs to the GART family. XX DR PROSITE; PS00373; GART; 1; trigger=no DR Pfam; PF00551; Formyl_trans_N; 1; trigger=no DR NCBIfam; TIGR00639; PurN; 1; trigger=no XX KW Purine biosynthesis KW Transferase XX GO GO:0004644; F:phosphoribosylglycinamide formyltransferase activity GO GO:0006189; P:'de novo' IMP biosynthetic process XX FT From: PUR3_ECOLI (P08179) FT BINDING 11..13 FT /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" FT /ligand_id="ChEBI:CHEBI:143788" FT Optional; Condition: G-[ST]-N FT BINDING 89..92 FT /ligand="(6R)-10-formyltetrahydrofolate" FT /ligand_id="ChEBI:CHEBI:195366" FT Optional; Condition: [MLF]-[RK]-[IL]-[LVI] FT ACT_SITE 108 FT /note="Proton donor" FT Condition: H FT BINDING 64 FT /ligand="(6R)-10-formyltetrahydrofolate" FT /ligand_id="ChEBI:CHEBI:195366" FT Optional; Condition: [RK] FT BINDING 106 FT /ligand="(6R)-10-formyltetrahydrofolate" FT /ligand_id="ChEBI:CHEBI:195366" FT Optional; Condition: N FT SITE 144 FT /note="Raises pKa of active site His" FT Optional; Condition: D XX Size: 169-270; Related: None; Template: P08179; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.10 2023/07/18 //