AC MF_01933; DC Protein; auto TR HAMAP; MF_01933; -; 1; level=0 XX Names: MenC_2 XX ID MENC DE RecName: Full=o-succinylbenzoate synthase; DE Short=OSB synthase; DE Short=OSBS; DE EC=4.2.1.113; DE AltName: Full=4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; DE AltName: Full=o-succinylbenzoic acid synthase; GN Name=menC; XX CC -!- FUNCTION: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- CC carboxylate (SHCHC) to 2-succinylbenzoate (OSB). CC -!- CATALYTIC ACTIVITY: CC Reaction=(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate CC = 2-succinylbenzoate + H2O; Xref=Rhea:RHEA:10196, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:18325, ChEBI:CHEBI:58689; EC=4.2.1.113; CC -!- COFACTOR: CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; CC -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate CC biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7. case not CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. else case CC -!- PATHWAY: Cofactor biosynthesis; phylloquinone biosynthesis. end case CC -!- SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing CC enzyme family. MenC type 2 subfamily. XX DR Pfam; PF02746; MR_MLE_N; 1; trigger=no DR Pfam; PF01188; MR_MLE; 0-1; trigger=no DR NCBIfam; TIGR01928; menC_lowGC/arch; 1; trigger=no XX case not KW Menaquinone biosynthesis end case KW Lyase case KW Magnesium KW Metal-binding end case XX GO GO:0016836; F:hydro-lyase activity case GO GO:0000287; F:magnesium ion binding end case case not GO GO:0009234; P:menaquinone biosynthetic process else case GO GO:0042372; P:phylloquinone biosynthetic process end case XX FT From: MENC_BACSU (O34514) FT ACT_SITE 164 FT /note="Proton donor" FT Condition: K FT ACT_SITE 263 FT /note="Proton acceptor" FT Condition: K FT BINDING 189 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Group: 1; Condition: D FT BINDING 214 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Group: 1; Condition: E FT BINDING 239 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Group: 1; Condition: D XX Size: 328-400; Related: None; Template: O34514; P29208; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.10 2023/06/01 //