AC   MF_01936;
DC   Protein; auto
TR   HAMAP; MF_01936; -; 1; level=0
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Names: MenI
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ID   MENI
DE   RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
DE            Short=DHNA-CoA hydrolase;
DE            EC=3.1.2.28;
DE   AltName: Full=DHNA-CoA thioesterase;
GN   Name=menI;
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CC   -!- FUNCTION: Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA
CC       (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-
CC         naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58897; EC=3.1.2.28;
CC   -!- PATHWAY: Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate
CC       biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC   -!- SUBUNIT: Homotetramer. Dimer of dimers.
CC   -!- SIMILARITY: Belongs to the thioesterase PaaI family.
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DR   Pfam; PF03061; 4HBT; 1; trigger=no
DR   NCBIfam; TIGR00369; unchar_dom_1; 1; trigger=no
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KW   Hydrolase
KW   Menaquinone biosynthesis
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GO   GO:0016790; F:thiolester hydrolase activity
GO   GO:0009234; P:menaquinone biosynthetic process
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FT   From: MENI_ECOLI (P77781)
FT   BINDING         89..92
FT                   /ligand="substrate"
FT   Optional; Condition: H-[VIL]-[RK]-[SA]
FT   BINDING         106..111
FT                   /ligand="substrate"
FT   Optional; Condition: H-[VL]-G-[SAT]-R-H
FT   ACT_SITE        63
FT                   /note="Nucleophile or proton acceptor"
FT   Condition: E
FT   BINDING         82
FT                   /ligand="substrate"
FT   Optional; Condition: G
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Size: 130-160;
Related: None;
Template: P77781;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: The profile and the rule are currently restricted to Enterobacterales.
 Further characterization is needed for other species.
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# Revision 1.7 2023/06/01
//