AC   MF_01940;
DC   Protein; auto
TR   HAMAP; MF_01940; -; 1; level=0
XX
Names: RNA_CPDase
XX
ID   THPR
DE   RecName: Full=RNA 2',3'-cyclic phosphodiesterase;
DE            Short=RNA 2',3'-CPDase;
DE            EC=3.1.4.58;
case <OC:Escherichia> or <OC:Shigella>
GN   Name=thpR;
end case
XX
CC   -!- FUNCTION: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-
CC       phosphomonoester.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-
CC         end 2'-phospho-ribonucleotide-RNA + H(+); Xref=Rhea:RHEA:11828,
CC         Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:17353, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:83064, ChEBI:CHEBI:173113;
CC         EC=3.1.4.58;
CC   -!- SIMILARITY: Belongs to the 2H phosphoesterase superfamily. ThpR family.
XX
DR   Pfam; PF02834; LigT_PEase; 2; trigger=no
DR   NCBIfam; TIGR02258; 2_5_ligase; 1; trigger=no
XX
KW   Hydrolase
XX
GO   GO:0008081; F:phosphoric diester hydrolase activity
XX
FT   From: THPR_ECOLI (P37025)
FT   MOTIF           43..46
FT                   /note="HXTX 1"
FT   Condition: H-x-T-x
FT   MOTIF           125..128
FT                   /note="HXTX 2"
FT   Condition: H-x-T-x
FT   ACT_SITE        43
FT                   /note="Proton donor"
FT   Condition: H
FT   ACT_SITE        125
FT                   /note="Proton acceptor"
FT   Condition: H
XX
Size: 153-320;
Related: None;
Template: P37025; Q8U4Q3; Q5SHB1;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Was originally thought to be a 2',5'-RNA ligase.
XX
# Revision 1.6 2023/06/01
//