AC   MF_01944;
DC   Protein; auto
TR   HAMAP; MF_01944; -; 1; level=0
XX
Names: Lipid_A_LpxM
XX
ID   LPXM
case <OC:Escherichia>
DE   RecName: Full=Lipid A biosynthesis myristoyltransferase;
DE            EC=2.3.1.243;
DE   AltName: Full=Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase;
else
DE   RecName: Full=Lipid A biosynthesis acyltransferase;
DE            EC=2.3.1.243;
DE   AltName: Full=Kdo(2)-lauroyl-lipid IV(A) acyltransferase;
end case
GN   Name=lpxM;
XX
case <OC:Escherichia>
CC   -!- FUNCTION: Catalyzes the transfer of myristate from myristoyl-[acyl-
CC       carrier-protein] (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-
CC       lipid A.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E.
CC         coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid
CC         A (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:28438, Rhea:RHEA-COMP:9648,
CC         Rhea:RHEA-COMP:9685, ChEBI:CHEBI:58540, ChEBI:CHEBI:61524,
CC         ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=2.3.1.243;
else
CC   -!- FUNCTION: Catalyzes the transfer of an acyl chain from an acyl-[acyl-
CC       carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-
CC       lipid A.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-
CC         (acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A +
CC         holo-[ACP]; Xref=Rhea:RHEA:69400, Rhea:RHEA-COMP:9685, Rhea:RHEA-
CC         COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651,
CC         ChEBI:CHEBI:176430, ChEBI:CHEBI:176431; EC=2.3.1.243;
end case
CC   -!- PATHWAY: Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-
CC       lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step
CC       4/4.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
XX
DR   Pfam; PF03279; Lip_A_acyltrans; 1; trigger=no
DR   NCBIfam; TIGR02208; lipid_A_msbB; 1; trigger=no
DR   PIRSF; PIRSF026649; MsbB; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=yes
XX
KW   Acyltransferase
KW   Cell inner membrane
KW   Cell membrane
KW   Lipopolysaccharide biosynthesis
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
case <OC:Escherichia>
GO   GO:0019107; F:myristoyltransferase activity
else
GO   GO:0016746; F:acyltransferase activity
end case
GO   GO:0036104; P:Kdo2-lipid A biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: LPXM_ECOLI (P24205)
FT   MOTIF           139..144
FT                   /note="HXXXXD motif"
FT   Condition: H-x-x-x-x-[DE]
XX
Size: 290-365;
Related: None;
Template: P24205;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in SHIFL
Plasmid: in SHIFL
Comments: None
XX
# Revision 1.8 2023/06/01
//