AC   MF_01945;
DC   Protein; auto
TR   HAMAP; MF_01945; -; 1; level=0
XX
Names: Lipid_A_LpxT
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ID   LPXT
DE   RecName: Full=Lipid A 1-diphosphate synthase;
DE            EC=2.7.4.29;
DE   AltName: Full=Kdo(2)-lipid A phosphotransferase;
DE   AltName: Full=Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase;
GN   Name=lpxT;
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CC   -!- FUNCTION: Involved in the modification of the lipid A domain of
CC       lipopolysaccharides (LPS). Transfers a phosphate group from
CC       undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-
CC       diphosphate. Contributes to the recycling of undecaprenyl phosphate
CC       (C55-P).
case <OC:Escherichia>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-
CC         trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-
CC         diphosphate + di-trans,octa-cis-undecaprenyl phosphate;
CC         Xref=Rhea:RHEA:45468, ChEBI:CHEBI:58405, ChEBI:CHEBI:58540,
CC         ChEBI:CHEBI:60392, ChEBI:CHEBI:85271; EC=2.7.4.29;
else
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-
CC         cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-
CC         (2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl
CC         phosphate; Xref=Rhea:RHEA:74291, ChEBI:CHEBI:58405,
CC         ChEBI:CHEBI:60392, ChEBI:CHEBI:176431, ChEBI:CHEBI:193150;
CC         EC=2.7.4.29;
end case
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC       Note=Transferase activity takes place on the periplamic side of the
CC       inner membrane.
CC   -!- SIMILARITY: Belongs to the LpxT phosphotransferase family.
XX
DR   Pfam; PF01569; PAP2; 1; trigger=no
DR   General; Transmembrane; -; 5-6; trigger=yes
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KW   Cell inner membrane
KW   Cell membrane
KW   Lipopolysaccharide biosynthesis
KW   Membrane
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0016776; F:phosphotransferase activity, phosphate group as acceptor
GO   GO:0009245; P:lipid A biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   None
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Size: 216-262;
Related: None;
Template: P76445;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.7 2022/09/29
//