AC   MF_01956;
DC   Protein; auto
TR   HAMAP; MF_01956; -; 1; level=0
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Names: MUG
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ID   MUG
DE   RecName: Full=G/U mismatch-specific DNA glycosylase;
DE            EC=3.2.2.28;
DE   AltName: Full=Double-strand-specific uracil glycosylase;
DE   AltName: Full=Mismatch-specific uracil DNA-glycosylase;
DE            Short=MUG;
GN   Name=mug;
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CC   -!- FUNCTION: Excises ethenocytosine and uracil, which can arise by
CC       alkylation or deamination of cytosine, respectively, from the
CC       corresponding mispairs with guanine in ds-DNA. It is capable of
CC       hydrolyzing the carbon-nitrogen bond between the sugar-phosphate
CC       backbone of the DNA and the mispaired base. The complementary strand
CC       guanine functions in substrate recognition. Required for DNA damage
CC       lesion repair in stationary-phase cells.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Specifically hydrolyzes mismatched double-stranded DNA and
CC         polynucleotides, releasing free uracil.; EC=3.2.2.28;
CC   -!- SUBUNIT: Binds DNA as a monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC       TDG/mug family.
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DR   Pfam; PF03167; UDG; 1; trigger=no
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KW   Cytoplasm
KW   DNA damage
KW   DNA excision
KW   DNA repair
KW   DNA-binding
KW   Hydrolase
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GO   GO:0008263; F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO   GO:0006285; P:base-excision repair, AP site formation
GO   GO:0005737; C:cytoplasm
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FT   None
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Size: 162-168;
Related: None;
Template: P0A9H1;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in
 position 118. The sequence has been checked and is believed to be correct
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# Revision 1.14 2019/11/19
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