AC   MF_01965;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_01965; -; 1; level=0
XX
Names: NADHX_dehydratase
XX
ID   NNRD
DE   RecName: Full=ADP-dependent (S)-NAD(P)H-hydrate dehydratase;
DE            EC=4.2.1.136;
DE   AltName: Full=ADP-dependent NAD(P)HX dehydratase;
GN   Name=nnrD;
XX
CC   -!- FUNCTION: Catalyzes the dehydration of the S-form of NAD(P)HX at the
CC       expense of ADP, which is converted to AMP. Together with NAD(P)HX
CC       epimerase, which catalyzes the epimerization of the S- and R-forms, the
CC       enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of
CC       NAD(P)H that is a result of enzymatic or heat-dependent hydration.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate;
CC         Xref=Rhea:RHEA:32223, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:64074, ChEBI:CHEBI:456215,
CC         ChEBI:CHEBI:456216; EC=4.2.1.136;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate;
CC         Xref=Rhea:RHEA:32235, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:64076, ChEBI:CHEBI:456215,
CC         ChEBI:CHEBI:456216; EC=4.2.1.136;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the NnrD/CARKD family.
XX
DR   PROSITE; PS01049; YJEF_C_1; 1; trigger=no
DR   PROSITE; PS01050; YJEF_C_2; 1; trigger=no
DR   PROSITE; PS51383; YJEF_C_3; 1; trigger=yes
DR   Pfam; PF01256; Carb_kinase; 1; trigger=no
DR   NCBIfam; TIGR00196; YjeF_C; 1; trigger=no
XX
KW   ATP-binding
KW   Lyase
KW   NAD
KW   NADP
KW   Nucleotide-binding
XX
GO   GO:0052855; F:ADP-dependent NAD(P)H-hydrate dehydratase activity
GO   GO:0046496; P:nicotinamide nucleotide metabolic process
XX
FT   From: NNRD_BACSU (P94368)
FT   BINDING         186..190
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: K-x(3)-[ST]
FT   BINDING         42
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: A
FT   BINDING         104
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: G
FT   BINDING         149
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: H
FT   BINDING         215
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: G
FT   BINDING         216
FT                   /ligand="(6S)-NADPHX"
FT                   /ligand_id="ChEBI:CHEBI:64076"
FT   Condition: D
XX
Size: 257-304;
Related: None;
Template: P94368; P31806; Q9X024;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_01966 (nrrE)
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/06/01
//