AC   MF_01967;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_01967; -; 1; level=0
XX
Names: Sirtuin_ClassII
XX
ID   NPD
DE   RecName: Full=NAD-dependent protein deacetylase;
DE            EC=2.3.1.286;
DE   AltName: Full=Regulatory protein SIR2 homolog;
GN   Name=cobB;
XX
CC   -!- FUNCTION: NAD-dependent protein deacetylase which modulates the
CC       activities of several enzymes which are inactive in their acetylated
CC       form.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-
CC         ADP-D-ribose + L-lysyl-[protein] + nicotinamide;
CC         Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767;
CC         EC=2.3.1.286;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the sirtuin family. Class II subfamily.
XX
DR   PROSITE; PS50305; SIRTUIN; 1; trigger=yes
DR   Pfam; PF02146; SIR2; 1; trigger=no
XX
KW   Cytoplasm
KW   NAD
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
KW   Transferase
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0034979; F:NAD-dependent protein deacetylase activity
GO   GO:0070403; F:NAD+ binding
GO   GO:0006476; P:protein deacetylation
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: SIR4_HUMAN (Q9Y6E7)
FT   BINDING         62..82
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G-A-G-x-S-T-x-x-G-[IV]-P-D-Y-R-x(7)
FT   BINDING         143..146
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q-N-V-D
FT   BINDING         260..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G-[ST]-S
FT   BINDING         286..288
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N-x-G
FT   ACT_SITE        161
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         169
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         220
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         223
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         304
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
XX
Size: 273-373;
Related: MF_01121; MF_01968;
Template: Q9Y6E7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2022/11/19
//