AC   MF_01968;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_01968; -; 1; level=0
XX
Names: Sirtuin_ClassU
XX
ID   NPD
DE   RecName: Full=NAD-dependent protein deacetylase;
DE            EC=2.3.1.286;
DE   AltName: Full=Regulatory protein SIR2 homolog;
GN   Name=cobB;
XX
case <OC:Archaea>
CC   -!- FUNCTION: NAD-dependent protein deacetylase which modulates the
CC       activities of several enzymes which are inactive in their acetylated
CC       form. Deacetylates the N-terminal lysine residue of Alba, the major
CC       archaeal chromatin protein and that, in turn, increases Alba's DNA
CC       binding affinity, thereby repressing transcription.
else
CC   -!- FUNCTION: NAD-dependent protein deacetylase which modulates the
CC       activities of several enzymes which are inactive in their acetylated
CC       form.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-
CC         ADP-D-ribose + L-lysyl-[protein] + nicotinamide;
CC         Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767;
CC         EC=2.3.1.286;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the sirtuin family. Class U subfamily.
XX
DR   PROSITE; PS50305; SIRTUIN; 1; trigger=yes
DR   Pfam; PF02146; SIR2; 1; trigger=no
XX
KW   Cytoplasm
KW   NAD
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
case <OC:Archaea>
KW   Transcription
KW   Transcription regulation
end case
KW   Transferase
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0034979; F:NAD-dependent protein deacetylase activity
GO   GO:0070403; F:NAD+ binding
GO   GO:0006476; P:protein deacetylation
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: NPD_THEMA (Q9WYW0)
FT   ACT_SITE        116
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         22
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: A
FT   BINDING         26
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: T
FT   BINDING         33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [FY]
FT   BINDING         33
FT                   /ligand="nicotinamide"
FT                   /ligand_id="ChEBI:CHEBI:17154"
FT   Condition: [FY]
FT   BINDING         34
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R
FT   BINDING         98
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q
FT   BINDING         100
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [IVT]
FT   BINDING         100
FT                   /ligand="nicotinamide"
FT                   /ligand_id="ChEBI:CHEBI:17154"
FT   Condition: [IVT]
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: D
FT   BINDING         101
FT                   /ligand="nicotinamide"
FT                   /ligand_id="ChEBI:CHEBI:17154"
FT   Condition: D
FT   BINDING         116
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: H
FT   BINDING         124
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         127
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         151
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         189
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: [ST]
FT   BINDING         190
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: S
FT   BINDING         214
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N
FT   BINDING         215
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [LAV]
FT   BINDING         216
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G
FT   BINDING         231
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [DE]
FT   BINDING         232
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [VGIA]
XX
Size: 229-260;
Related: MF_01121!; MF_01967;
Template: Q9WYW0;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in GEOKA
Plasmid: None
Comments: None
XX
# Revision 1.11 2022/11/19
//