AC   MF_01969;
DC   Protein; auto
TR   HAMAP; MF_01969; -; 1; level=0
XX
Names: KynB
XX
ID   KYNB
DE   RecName: Full=Kynurenine formamidase;
DE            Short=KFase;
DE            Short=KFA;
DE            EC=3.5.1.9;
DE   AltName: Full=Arylformamidase;
DE   AltName: Full=N-formylkynurenine formamidase;
DE            Short=FKF;
GN   Name=kynB;
XX
CC   -!- FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-
CC       kynurenine, the second step in the kynurenine pathway of tryptophan
CC       degradation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine;
CC         Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 2 zinc ions per subunit.;
CC   -!- PATHWAY: Amino-acid degradation; L-tryptophan degradation via
CC       kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the Cyclase 1 superfamily. KynB family.
XX
DR   Pfam; PF04199; Cyclase; 1; trigger=no
DR   NCBIfam; TIGR03035; Trp_arylform; 1; trigger=no
XX
KW   Hydrolase
KW   Metal-binding
KW   Tryptophan catabolism
KW   Zinc
XX
GO   GO:0004061; F:arylformamidase activity
GO   GO:0008270; F:zinc ion binding
GO   GO:0006569; P:tryptophan catabolic process
XX
FT   From: KYNB_BACAN (Q81PP9)
FT   ACT_SITE        60
FT                   /note="Proton donor/acceptor"
FT   Condition: H
FT   BINDING         50
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         54
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         56
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         161
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: H
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: E
FT   BINDING         20
FT                   /ligand="substrate"
FT   Condition: [WF]
XX
Size: 209-223;
Related: None;
Template: Q81CK1; Q9I234; P0C8P4; Q81PP9; B4E9I9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2023/06/01
//