AC   MF_01971;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_01971; -; 1; level=0
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Names: Kynurenine_monooxygenase
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ID   KMO
DE   RecName: Full=Kynurenine 3-monooxygenase;
DE            EC=1.14.13.9;
DE   AltName: Full=Kynurenine 3-hydroxylase;
GN   Name=kmo;
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CC   -!- FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form
CC       3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic
CC       acid.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine +
CC         H2O + NADP(+); Xref=Rhea:RHEA:20545, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:57959, ChEBI:CHEBI:58125, ChEBI:CHEBI:58349;
CC         EC=1.14.13.9;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from
CC       L-kynurenine: step 1/3.
CC   -!- SIMILARITY: Belongs to the aromatic-ring hydroxylase family. KMO
CC       subfamily.
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DR   Pfam; PF01266; DAO; 1; trigger=no
DR   PRINTS; PR00420; RNGMNOXGNASE; 1; trigger=no
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KW   FAD
KW   Flavoprotein
KW   Monooxygenase
KW   NADP
KW   Oxidoreductase
KW   Pyridine nucleotide biosynthesis
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GO   GO:0004502; F:kynurenine 3-monooxygenase activity
GO   GO:0050660; F:flavin adenine dinucleotide binding
GO   GO:0006569; P:tryptophan catabolic process
GO   GO:0019805; P:quinolinate biosynthetic process
GO   GO:0034354; P:'de novo' NAD biosynthetic process from tryptophan
GO   GO:0043420; P:anthranilate metabolic process
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FT   None
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Size: 427-600;
Related: None;
Template: Q84HF5; Q11PP7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.10 2019/11/19
//