AC   MF_01988;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_01988; -; 1; level=0
XX
Names: Succ_CoA_alpha
XX
ID   SUCD
DE   RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha;
DE            EC=6.2.1.5;
DE   AltName: Full=Succinyl-CoA synthetase subunit alpha;
DE            Short=SCS-alpha;
GN   Name=sucD;
XX
CC   -!- FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle
CC       (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of
CC       either ATP or GTP and thus represents the only step of substrate-level
CC       phosphorylation in the TCA. The alpha subunit of the enzyme binds the
CC       substrates coenzyme A and phosphate, while succinate binding and
CC       nucleotide specificity is provided by the beta subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA;
CC         Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
CC         ChEBI:CHEBI:456216; EC=6.2.1.5;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17663;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + GTP + succinate = GDP + phosphate + succinyl-CoA;
CC         Xref=Rhea:RHEA:22120, ChEBI:CHEBI:30031, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
CC         ChEBI:CHEBI:58189;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:22122;
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate
CC       from succinyl-CoA (ligase route): step 1/1.
CC   -!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
CC   -!- SIMILARITY: Belongs to the succinate/malate CoA ligase alpha subunit
CC       family.
XX
DR   PROSITE; PS01216; SUCCINYL_COA_LIG_1; 1; trigger=no
DR   PROSITE; PS00399; SUCCINYL_COA_LIG_2; 1; trigger=no
DR   Pfam; PF02629; CoA_binding; 1; trigger=no
DR   Pfam; PF00549; Ligase_CoA; 1; trigger=no
DR   Pfam; PF13607; Succ_CoA_lig; 1; trigger=no
DR   PRINTS; PR01798; SCOASYNTHASE; 1; trigger=no
DR   NCBIfam; TIGR01019; sucCoAalpha; 1; trigger=no
DR   PIRSF; PIRSF001553; SucCS_alpha; 1; trigger=no
XX
KW   Ligase
KW   Nucleotide-binding
KW   Tricarboxylic acid cycle
XX
GO   GO:0004775; F:succinate-CoA ligase (ADP-forming) activity
GO   GO:0006099; P:tricarboxylic acid cycle
XX
FT   From: SUCD_ECOLI (P0AGE9)
FT   BINDING         17..20
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: T-G-x(2)
FT   BINDING         96..98
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: [IVL]-T-[ED]
FT   ACT_SITE        247
FT                   /note="Tele-phosphohistidine intermediate"
FT   Condition: H
FT   BINDING         43
FT                   /ligand="CoA"
FT                   /ligand_id="ChEBI:CHEBI:57287"
FT   Condition: K
FT   BINDING         159
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared with subunit beta"
FT   Condition: Y
XX
Size: 259-308;
Related: None;
Template: P0AGE9; P09143; O19069;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARCFU, CITK8, STRCO
Plasmid: None
Comments: None
XX
# Revision 1.9 2023/06/01
//