AC   MF_02016;
DC   Protein; auto
TR   HAMAP; MF_02016; -; 1; level=0
XX
Names: MltF
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ID   MLTF
DE   RecName: Full=Membrane-bound lytic murein transglycosylase F;
DE            EC=4.2.2.n1;
DE   AltName: Full=Murein lyase F;
DE   Flags: Precursor;
GN   Name=mltF;
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CC   -!- FUNCTION: Murein-degrading enzyme that degrades murein glycan strands
CC       and insoluble, high-molecular weight murein sacculi, with the
CC       concomitant formation of a 1,6-anhydromuramoyl product. Lytic
CC       transglycosylases (LTs) play an integral role in the metabolism of the
CC       peptidoglycan (PG) sacculus. Their lytic action creates space within
CC       the PG sacculus to allow for its expansion as well as for the insertion
CC       of various structures such as secretion systems and flagella.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exolytic cleavage of the (1->4)-beta-glycosidic linkage
CC         between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine
CC         (GlcNAc) residues in peptidoglycan, from either the reducing or the
CC         non-reducing ends of the peptidoglycan chains, with concomitant
CC         formation of a 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n1;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Peripheral membrane protein.
CC       Note=Attached to the inner leaflet of the outer membrane.
CC   -!- DOMAIN: The N-terminal domain does not have lytic activity and probably
CC       modulates enzymatic activity. The C-terminal domain is the catalytic
CC       active domain.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the bacterial solute-
CC       binding protein 3 family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the transglycosylase
CC       Slt family.
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DR   PROSITE; PS00922; TRANSGLYCOSYLASE; 1; trigger=no
DR   Pfam; PF00497; SBP_bac_3; 1; trigger=no
DR   Pfam; PF01464; SLT; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
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KW   Cell outer membrane
KW   Cell wall biogenesis/degradation
KW   Lyase
KW   Membrane
KW   Signal
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GO   GO:0016998; P:cell wall macromolecule catabolic process
GO   GO:0008933; F:lytic transglycosylase activity
GO   GO:0009279; C:cell outer membrane
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FT   From: MLTF_ECOLI (P0AGC5)
FT   REGION          22..269
FT                   /note="Non-LT domain"
FT   REGION          270..Cter
FT                   /note="LT domain"
FT   ACT_SITE        314
FT   Condition: E
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Size: 450-537;
Related: None;
Template: P0AGC5;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in ALKEH
Plasmid: None
Comments: None
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# Revision 1.14 2023/01/26
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