AC   MF_02020;
DC   Protein; auto
TR   HAMAP; MF_02020; -; 1; level=0
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Names: Mpl
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ID   MPL
DE   RecName: Full=UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase;
DE            EC=6.3.2.45;
DE   AltName: Full=Murein peptide ligase;
DE   AltName: Full=UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase;
GN   Name=mpl;
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CC   -!- FUNCTION: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-
CC       meso-diaminopimelate by linking it to UDP-N-acetylmuramate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-
CC         meso-2,6-diaminopimelate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-
CC         alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate + ADP + phosphate +
CC         H(+); Xref=Rhea:RHEA:29563, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:61401, ChEBI:CHEBI:70757,
CC         ChEBI:CHEBI:83905, ChEBI:CHEBI:456216; EC=6.3.2.45;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC   -!- SIMILARITY: Belongs to the MurCDEF family. Mpl subfamily.
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DR   Pfam; PF01225; Mur_ligase; 1; trigger=no
DR   Pfam; PF02875; Mur_ligase_C; 1; trigger=no
DR   Pfam; PF08245; Mur_ligase_M; 1; trigger=no
DR   NCBIfam; TIGR01081; mpl; 1; trigger=no
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KW   ATP-binding
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Ligase
KW   Magnesium
KW   Nucleotide-binding
KW   Peptidoglycan synthesis
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GO   GO:0005524; F:ATP binding
GO   GO:0016881; F:acid-amino acid ligase activity
GO   GO:0009254; P:peptidoglycan turnover
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FT   From: MPL_ECOLI (P37773)
FT   BINDING         110..116
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-[ST]-x-G-K-T-[ST]
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Size: 435-505;
Related: None;
Template: P37773;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Version: 11
# Last updated date: 2024-12-17
# Created date: 2015-02-17
//