AC   MF_02023;
DC   Protein; auto
TR   HAMAP; MF_02023; -; 1; level=0
XX
Names: Sulfite_red
XX
ID   MCCA
DE   RecName: Full=Dissimilatory sulfite reductase;
DE            EC=1.8.99.-;
DE   Flags: Precursor;
XX
CC   -!- FUNCTION: Respiratory sulfite reductase that catalyzes the reduction of
CC       sulfite to sulfide in a single step, consuming six electrons in the
CC       process.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-disulfide + 2 A + 3 H2O + hydrogen sulfide =
CC         [protein]-dithiol + 2 AH2 + H(+) + sulfite; Xref=Rhea:RHEA:51676,
CC         Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:29919, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:50058;
CC   -!- COFACTOR:
CC       Name=Cu(+); Xref=ChEBI:CHEBI:49552;
CC       Note=Exposure to oxygen reduces copper binding and leads to the
CC       formation of a disulfide bond between the two Cys residues that bind
CC       the copper ion.;
CC   -!- COFACTOR:
CC       Name=heme c; Xref=ChEBI:CHEBI:61717;
CC       Note=Binds 8 heme c groups covalently per monomer.;
CC   -!- PATHWAY: Sulfur metabolism; sulfite reduction.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the multiheme cytochrome c family.
XX
DR   PROSITE; PS51008; MULTIHEME_CYTC; 2; trigger=no
DR   Pfam; PF14522; Cytochrome_C7; 1; trigger=no
DR   Pfam; PF09699; Paired_CXXCH_1; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
XX
KW   Copper
KW   Electron transport
KW   Heme
KW   Iron
KW   Metal-binding
KW   Oxidoreductase
KW   Periplasm
KW   Signal
KW   Sulfate respiration
KW   Transport
XX
GO   GO:0005507; F:copper ion binding
GO   GO:0020037; F:heme binding
GO   GO:0005506; F:iron ion binding
GO   GO:0016002; F:sulfite reductase activity
GO   GO:0070814; P:hydrogen sulfide biosynthetic process
GO   GO:0042597; C:periplasmic space
XX
FT   From: MCCA_WOLSU (Q7MSJ8)
FT   BINDING         159
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="1"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         171
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="4"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         318
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="2"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         355
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="3"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         360
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="1"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         376
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="4"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         411
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT   Condition: C
FT   BINDING         423
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="6"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         434
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="5"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         437
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="3"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         478
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="6"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         491
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="8"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         500
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="7"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         507
FT                   /ligand="Cu(+)"
FT                   /ligand_id="ChEBI:CHEBI:49552"
FT   Condition: C
FT   BINDING         528
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="5"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         591
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="8"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         675
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="7"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         155
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="1"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         158
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="1"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         220
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         297
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         314
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="2"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         317
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="2"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         351
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="3"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         354
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="3"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         372
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="4"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         375
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="4"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         378
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         430
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="5"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         433
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="5"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         474
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="6"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         477
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="6"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         496
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="7"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         499
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="7"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         574
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="8"
FT                   /note="covalent"
FT   Condition: C
FT   BINDING         590
FT                   /ligand="heme c"
FT                   /ligand_id="ChEBI:CHEBI:61717"
FT                   /ligand_label="8"
FT                   /note="covalent"
FT   Condition: C
XX
Size: 640-710;
Related: None;
Template: Q7MSJ8; Q8EJI6;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/01/26
//