AC   MF_02027;
DC   Protein; auto
TR   HAMAP; MF_02027; -; 1; level=0
XX
Names: WecD_RffC
XX
ID   WECD
DE   RecName: Full=dTDP-fucosamine acetyltransferase;
DE            EC=2.3.1.210;
DE   AltName: Full=TDP-fucosamine acetyltransferase;
DE   AltName: Full=dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
GN   Name=wecD;
XX
CC   -!- FUNCTION: Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-
CC       4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the
CC       biosynthesis of the enterobacterial common antigen (ECA).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA
CC         + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + H(+);
CC         Xref=Rhea:RHEA:34443, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:68492, ChEBI:CHEBI:68493;
CC         EC=2.3.1.210;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC       antigen biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the WecD family.
XX
DR   PROSITE; PS51186; GNAT; 1; trigger=yes
DR   Pfam; PF00583; Acetyltransf_1; 1; trigger=no
DR   NCBIfam; TIGR02382; wecD_rffC; 1; trigger=no
XX
KW   Acyltransferase
KW   Transferase
XX
GO   GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups
GO   GO:0009246; P:enterobacterial common antigen biosynthetic process
XX
FT   From: WECD_ECOL6 (Q8FBQ3)
FT   BINDING         168..174
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   ACT_SITE        208
FT                   /note="Proton donor"
FT   Condition: Y
FT   BINDING         201
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Condition: N
FT   BINDING         207
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT   Condition: R
XX
Size: 180-260;
Related: None;
Template: Q8FBQ3;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2023/06/01
//