AC MF_02034; DC Protein; auto TR HAMAP; MF_02034; -; 1; level=0 XX Names: EgtA XX ID EGTA DE RecName: Full=Glutamate--cysteine ligase EgtA; DE EC=6.3.2.2; DE AltName: Full=Gamma-glutamylcysteine synthase; DE Short=GCS; DE Short=Gamma-ECS; GN Name=egtA; XX CC -!- FUNCTION: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). CC This compound is used as substrate for the biosynthesis of the low- CC molecular thiol compound ergothioneine. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2; CC -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis. CC -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 2 family. CC EgtA subfamily. XX DR Pfam; PF04107; GCS2; 1; trigger=no DR NCBIfam; TIGR03444; EgtA_Cys_ligase; 1; trigger=no XX KW ATP-binding KW Ligase KW Nucleotide-binding XX GO GO:0005524; F:ATP binding GO GO:0004357; F:glutamate-cysteine ligase activity GO GO:0052699; P:ergothioneine biosynthetic process XX Size: 380-502; Related: None; Template: P9WPK7; A0R5N1; Scope: Bacteria; Actinomycetota Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.6 2023/06/01 //