AC   MF_02035;
DC   Protein; auto
TR   HAMAP; MF_02035; -; 1; level=0
XX
Names: EgtB
XX
ID   EGTB
DE   RecName: Full=Hercynine oxygenase;
DE            EC=1.14.99.50;
DE   AltName: Full=Gamma-glutamyl hercynylcysteine S-oxide synthase;
GN   Name=egtB;
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CC   -!- FUNCTION: Catalyzes the oxidative sulfurization of hercynine (N-
CC       alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-
CC       glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of
CC       ergothioneine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-
CC         glutamyl-hercynylcysteine S-oxide + H2O; Xref=Rhea:RHEA:42672,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:15781,
CC         ChEBI:CHEBI:58173, ChEBI:CHEBI:82703; EC=1.14.99.50;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC   -!- SIMILARITY: Belongs to the EgtB family.
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DR   Pfam; PF12867; DinB_2; 1; trigger=no
DR   Pfam; PF03781; FGE-sulfatase; 1; trigger=no
DR   NCBIfam; TIGR03440; egtB_TIGR03440; 1; trigger=no
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KW   Iron
KW   Metal-binding
KW   Monooxygenase
KW   Oxidoreductase
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GO   GO:0005506; F:iron ion binding
GO   GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO   GO:0052699; P:ergothioneine biosynthetic process
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FT   From: EGTB_MYCT3 (G7CFI3)
FT   BINDING         87..90
FT                   /ligand="gamma-L-glutamyl-L-cysteine"
FT                   /ligand_id="ChEBI:CHEBI:58173"
FT   Optional; Condition: R-x-x-R
FT   BINDING         51
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         134
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         138
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         416
FT                   /ligand="gamma-L-glutamyl-L-cysteine"
FT                   /ligand_id="ChEBI:CHEBI:58173"
FT   Optional; Condition: D
FT   BINDING         420
FT                   /ligand="gamma-L-glutamyl-L-cysteine"
FT                   /ligand_id="ChEBI:CHEBI:58173"
FT   Optional; Condition: R
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Size: 414-510;
Related: None;
Template: G7CFI3; A0R5N0;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.11 2023/06/01
//