AC   MF_02037;
DC   Protein; auto
TR   HAMAP; MF_02037; -; 1; level=0
XX
Names: EgtD
XX
ID   EGTD
DE   RecName: Full=Histidine N-alpha-methyltransferase;
DE            EC=2.1.1.44;
DE   AltName: Full=Histidine trimethyltransferase;
GN   Name=egtD;
XX
CC   -!- FUNCTION: Catalyzes the SAM-dependent triple methylation of the alpha-
CC       amino group of histidine to form hercynine, a step in the biosynthesis
CC       pathway of ergothioneine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine +
CC         3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38471, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15781, ChEBI:CHEBI:57595, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.44;
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. EgtD family.
XX
DR   Pfam; PF10017; Methyltransf_33; 1; trigger=no
DR   NCBIfam; TIGR03438; egtD_ergothio; 1; trigger=no
DR   PIRSF; PIRSF018005; UCP018005; 1; trigger=no
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0030745; F:dimethylhistidine N-methyltransferase activity
GO   GO:0052699; P:ergothioneine biosynthetic process
XX
FT   From: EGTD_MYCS2 (A0R5M8)
FT   BINDING         141..142
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D-[FMLY]
FT   BINDING         282..284
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT   Optional; Condition: E-[VI]-S
FT   BINDING         56
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT   Condition: Y
FT   BINDING         86
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: G
FT   BINDING         92
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: K
FT   BINDING         113
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
FT   BINDING         166
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT   Optional; Condition: N
FT   BINDING         206
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT   Optional; Condition: Y
XX
Size: 311-400;
Related: None;
Template: A0R5M8;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/06/01
//