AC   MF_02039;
DC   Protein; auto
TR   HAMAP; MF_02039; -; 1; level=0
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Names: FtsN_entero
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ID   FTSN
DE   RecName: Full=Cell division protein FtsN;
GN   Name=ftsN;
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CC   -!- FUNCTION: Essential cell division protein that activates septal
CC       peptidoglycan synthesis and constriction of the cell. Acts on both
CC       sides of the membrane, via interaction with FtsA in the cytoplasm and
CC       interaction with the FtsQBL complex in the periplasm. These
CC       interactions may induce a conformational switch in both FtsA and
CC       FtsQBL, leading to septal peptidoglycan synthesis by FtsI and
CC       associated synthases.
CC   -!- SUBUNIT: Interacts with FtsA via its N-terminal cytoplasmic domain.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass type II membrane
CC       protein. Note=Localizes to the septum. Localizes to the midcell via
CC       interaction with the early cell division protein FtsA and via the
CC       periplasmic SPOR domain.
CC   -!- SIMILARITY: Belongs to the FtsN family.
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DR   PROSITE; PS51724; SPOR; 1; trigger=yes
DR   Pfam; PF05036; SPOR; 1; trigger=no
DR   NCBIfam; TIGR02223; ftsN; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=yes
DR   ADD_TOPO_DOMAIN; Cytoplasmic; -; 1; trigger=yes
DR   ADD_TOPO_DOMAIN; Periplasmic; -; 1; trigger=yes
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KW   Cell cycle
KW   Cell division
KW   Cell inner membrane
KW   Cell membrane
KW   Membrane
KW   Septation
KW   Transmembrane
KW   Transmembrane helix
case <FTTag:disulfid>
KW   Disulfide bond
end case
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GO   GO:0090529; P:cell septum assembly
GO   GO:0043093; P:FtsZ-dependent cytokinesis
GO   GO:0032153; C:cell division site
GO   GO:0005886; C:plasma membrane
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FT   From: FTSN_ECOLI (P29131)
FT   REGION          4..6
FT                   /note="Mediates interaction with FtsA"
FT   Condition: [RK]-D-Y
FT   DISULFID        252..312
FT   Tag: disulfid; Condition: C-x*-C
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Size: 250-360;
Related: None;
Template: P29131;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: The N-terminus is often too short.
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# Revision 1.6 2023/06/01
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