AC   MF_02040;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea>
TR   HAMAP; MF_02040; -; 1; level=0
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Names: Mrp_NBP35
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ID   APBC
DE   RecName: Full=Iron-sulfur cluster carrier protein;
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CC   -!- FUNCTION: Binds and transfers iron-sulfur (Fe-S) clusters to target
CC       apoproteins. Can hydrolyze ATP.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the Mrp/NBP35 ATP-binding proteins family.
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DR   PROSITE; PS01215; MRP; 1; trigger=no
DR   Pfam; PF10609; ParA; 1; trigger=no
DR   Pfam; PF01883; DUF59; 0-1; trigger=no
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KW   ATP-binding
KW   Hydrolase
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   Nucleotide-binding
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GO   GO:0005524; F:ATP binding
GO   GO:0016887; F:ATP hydrolysis activity
GO   GO:0051536; F:iron-sulfur cluster binding
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FT   From: APBC_SALTY (Q8ZNN5)
FT   BINDING         115..122
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [GA]-K-G-G-V-G-K-[ST]
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Size: 235-460;
Related: MF_03038!; MF_03039!;
Template: Q8ZNN5; Q6LZC5;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Profile MF_02040 includes all members of the Mrp/NBP35 family. Rule MF_02040 annotates bacterial
 and archaeal matches. See MF_03038 for eukaryotic NUBP1/NBP35 subfamily and MF_03039 for eukaryotic
 NUBP2/CFD1 subfamily.
 The CXXC motif is thought to be required for Fe-S cluster binding. However, the individual
 cysteine residues in the CXXC motif seem dispensable (see APBC_SACS2). Other members lack this characteristic
 CXXC motif in the C terminus. More studies will be required to determine which residues are
 ligands for the Fe-S cluster in bacteria and archaea.
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# Revision 1.7 2022/11/19
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