AC   MF_02044;
DC   Protein; auto
TR   HAMAP; MF_02044; -; 1; level=0
XX
Names: Mre11
XX
ID   MRE11
DE   RecName: Full=DNA double-strand break repair protein Mre11;
DE            EC=3.1.-.-;
GN   Name=mre11;
XX
case <OC:Halobacteria>
CC   -!- FUNCTION: Part of the Rad50/Mre11 complex, which is involved in the
CC       early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB
CC       ends and has both double-stranded 3'-5' exonuclease activity and
CC       single-stranded endonuclease activity.
else
CC   -!- FUNCTION: Part of the Rad50/Mre11 complex, which is involved in the
CC       early steps of DNA double-strand break (DSB) repair. The complex may
CC       facilitate opening of the processed DNA ends to aid in the recruitment
CC       of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded
CC       3'-5' exonuclease activity and single-stranded endonuclease activity.
end case
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit.;
CC   -!- ACTIVITY REGULATION: Nuclease activity is regulated by Rad50.
CC   -!- SUBUNIT: Homodimer. Forms a heterotetramer composed of two Mre11
CC       subunits and two Rad50 subunits.
CC   -!- SIMILARITY: Belongs to the MRE11/RAD32 family.
XX
DR   Pfam; PF00149; Metallophos; 1; trigger=no
DR   Pfam; PF12850; Metallophos_2; 1; trigger=no
XX
KW   DNA damage
KW   DNA repair
KW   Endonuclease
KW   Exonuclease
KW   Hydrolase
KW   Manganese
KW   Metal-binding
KW   Nuclease
XX
GO   GO:0008408; F:3'-5' exonuclease activity
GO   GO:0004519; F:endonuclease activity
GO   GO:0030145; F:manganese ion binding
GO   GO:0045027; F:DNA end binding
GO   GO:0000403; F:Y-form DNA binding
GO   GO:0006302; P:double-strand break repair
XX
FT   From: MRE11_PYRFU (Q8U1N9)
FT   ACT_SITE        85
FT                   /note="Proton donor"
FT   Condition: H
FT   BINDING         8
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         10
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         49
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         49
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         84
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: [NDE]
FT   BINDING         173
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: H
FT   BINDING         206
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Optional; Condition: H
FT   BINDING         206
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Optional; Condition: D
FT   BINDING         208
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: H
XX
Size: 361-617;
Related: None;
Template: Q8U1N9; Q8NKQ0;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/11/19
//