AC   MF_02045;
DC   Protein; auto
TR   HAMAP; MF_02045; -; 1; level=0
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Names: PurE_classII
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ID   PURE
DE   RecName: Full=Phosphoribosylaminoimidazole carboxylase;
DE            EC=4.1.1.21;
DE   AltName: Full=AIR carboxylase;
DE            Short=AIRC;
GN   Name=purE;
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CC   -!- FUNCTION: Catalyzes the reversible conversion of 5-aminoimidazole
CC       ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole
CC       ribonucleotide (CAIR).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+)
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2;
CC         Xref=Rhea:RHEA:10792, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:137981; EC=4.1.1.21;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the AIR carboxylase family. Class II subfamily.
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DR   Pfam; PF00731; AIRC; 1; trigger=no
DR   NCBIfam; TIGR01162; purE; 1; trigger=no
DR   PIRSF; PIRSF001338; AIR_carboxylase; 1; trigger=no
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KW   Lyase
KW   Purine biosynthesis
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GO   GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity
GO   GO:0006189; P:'de novo' IMP biosynthetic process
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FT   From: PURE_TREDE (Q73PV9)
FT   BINDING         11
FT                   /ligand="substrate"
FT   Condition: S
FT   BINDING         14
FT                   /ligand="substrate"
FT   Condition: D
FT   BINDING         38
FT                   /ligand="substrate"
FT   Condition: S
FT   BINDING         41
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         67
FT                   /ligand="substrate"
FT   Condition: G
FT   BINDING         69
FT                   /ligand="substrate"
FT   Condition: S
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Size: 150-180;
Related: None;
Template: Q73PV9;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See rule MF_01929 for prokaryotic class I PurEs. Class I and class II PurEs are
 mechanistically related but bind different substrates.
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# Revision 1.5 2023/06/01
//