AC   MF_02047;
DC   Protein; auto
TR   HAMAP; MF_02047; -; 1; level=0
XX
Names: 6PGDH_archaea
XX
ID   6PGD
DE   RecName: Full=6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating;
DE            Short=6PGDH;
DE            EC=1.1.1.343;
XX
CC   -!- FUNCTION: Catalyzes the oxidative decarboxylation of 6-phosphogluconate
CC       to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to
CC       NADH.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-gluconate + NAD(+) = CO2 + D-ribulose 5-phosphate
CC         + NADH; Xref=Rhea:RHEA:33023, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58121, ChEBI:CHEBI:58759;
CC         EC=1.1.1.343;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
XX
DR   Pfam; PF00393; 6PGD; 1; trigger=no
DR   Pfam; PF03446; NAD_binding_2; 1; trigger=no
DR   PRINTS; PR00076; 6PGDHDRGNASE; 1; trigger=no
DR   NCBIfam; TIGR00872; gnd_rel; 1; trigger=no
XX
KW   Gluconate utilization
KW   NAD
KW   Oxidoreductase
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GO   GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO   GO:0051287; F:NAD binding
GO   GO:0009051; P:pentose-phosphate shunt, oxidative branch
XX
FT   From: 6PGD_HALVD (D4GST8)
FT   BINDING         7..12
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: G-L-G-R-M-G
FT   BINDING         67..69
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [VI]-P-A
FT   BINDING         118..120
FT                   /ligand="substrate"
FT   Optional; Condition: S-G-G
FT   BINDING         172..173
FT                   /ligand="substrate"
FT   Optional; Condition: H-N
FT   ACT_SITE        169
FT                   /note="Proton acceptor"
FT   Condition: K
FT   ACT_SITE        176
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         95
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: N
FT   BINDING         95
FT                   /ligand="substrate"
FT   Optional; Condition: N
FT   BINDING         118
FT                   /ligand="substrate"
FT   Optional; Condition: S
FT   BINDING         177
FT                   /ligand="substrate"
FT   Optional; Condition: Y
FT   BINDING         268
FT                   /ligand="substrate"
FT   Optional; Condition: R
XX
Size: 270-330;
Related: None;
Template: D4GST8;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2024/01/25
//