AC   MF_02056;
DC   Protein; auto
TR   HAMAP; MF_02056; -; 1; level=0
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Names: MetZ
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ID   METZ
DE   RecName: Full=O-succinylhomoserine sulfhydrylase;
DE            Short=OSH sulfhydrylase;
DE            Short=OSHS sulfhydrylase;
DE            EC=2.5.1.-;
GN   Name=metZ;
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CC   -!- FUNCTION: Catalyzes the formation of L-homocysteine from O-succinyl-L-
CC       homoserine (OSHS) and hydrogen sulfide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydrogen sulfide + O-succinyl-L-homoserine = L-homocysteine +
CC         succinate; Xref=Rhea:RHEA:27826, ChEBI:CHEBI:29919,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:57661, ChEBI:CHEBI:58199;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo
CC       pathway; L-homocysteine from O-succinyl-L-homoserine: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family. MetZ
CC       subfamily.
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DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1; trigger=no
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1; trigger=no
DR   NCBIfam; TIGR01325; O_suc_HS_sulf; 1; trigger=no
DR   PIRSF; PIRSF001434; CGS; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   Methionine biosynthesis
KW   Pyridoxal phosphate
KW   Transferase
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GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO   GO:0071266; P:'de novo' L-methionine biosynthetic process
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FT   From: METZ_MYCTU (P9WGB5)
FT   MOD_RES         219
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
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Size: 380-460;
Related: None;
Template: P55218; P9WGB5;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2023/06/01
//