AC   MF_02058;
DC   Protein; auto
TR   HAMAP; MF_02058; -; 1; level=0
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Names: Choline_CutC
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ID   CUTC
DE   RecName: Full=Choline trimethylamine-lyase;
DE            Short=Choline TMA-lyase;
DE            EC=4.3.99.4;
DE   AltName: Full=Choline utilization protein C;
GN   Name=cutC;
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CC   -!- FUNCTION: Glycine radical enzyme that catalyzes the cleavage of a C-N
CC       bond in choline, producing trimethylamine (TMA) and acetaldehyde.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=choline = acetaldehyde + trimethylamine; Xref=Rhea:RHEA:35095,
CC         ChEBI:CHEBI:15343, ChEBI:CHEBI:15354, ChEBI:CHEBI:58389; EC=4.3.99.4;
CC   -!- PATHWAY: Amine and polyamine metabolism; choline degradation.
CC   -!- PTM: Requires the activating protein CutD to generate the key active
CC       site glycyl radical on #{Gly-821} that is involved in catalysis.
CC   -!- SIMILARITY: Belongs to the glycyl radical enzyme (GRE) family. CutC
CC       subfamily.
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DR   PROSITE; PS00850; GLY_RADICAL_1; 1; trigger=no
DR   PROSITE; PS51149; GLY_RADICAL_2; 1; trigger=yes
DR   PROSITE; PS51554; PFL; 1; trigger=yes
DR   Pfam; PF01228; Gly_radical; 1; trigger=no
DR   Pfam; PF02901; PFL-like; 1; trigger=no
DR   NCBIfam; TIGR04394; choline_CutC; 1; trigger=no
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KW   Lyase
KW   Organic radical
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GO   GO:0016840; F:carbon-nitrogen lyase activity
GO   GO:0042426; P:choline catabolic process
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FT   From: CUTC_OLEA2 (Q30W70)
FT   ACT_SITE        489
FT                   /note="Cysteine radical intermediate"
FT   Condition: C
FT   ACT_SITE        491
FT                   /note="Proton acceptor"
FT   Condition: E
FT   MOD_RES         821
FT                   /note="Glycine radical"
FT   Condition: G
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Size: 785-1200;
Related: None;
Template: Q30W70;
Scope:
 Bacteria; Coriobacteriales
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.8 2023/06/01
//