AC   MF_02060;
DC   Protein; auto
TR   HAMAP; MF_02060; -; 1; level=0
XX
Names: tRNA_methyltr_TrmH
XX
ID   TRMH
DE   RecName: Full=tRNA (guanosine(18)-2'-O)-methyltransferase;
DE            EC=2.1.1.34;
DE   AltName: Full=tRNA [Gm18] methyltransferase;
GN   Name=trmH;
XX
CC   -!- FUNCTION: Catalyzes the 2'-O methylation of guanosine at position 18 in
CC       tRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-
CC         methylguanosine(18) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:20077, Rhea:RHEA-COMP:10190, Rhea:RHEA-COMP:10192,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.34;
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family.
XX
DR   Pfam; PF12105; SpoU_methylas_C; 1; trigger=no
DR   Pfam; PF00588; SpoU_methylase; 1; trigger=no
XX
KW   Methyltransferase
KW   RNA-binding
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
KW   tRNA-binding
XX
GO   GO:0141100; F:tRNA (guanine(18)-2'-O)-methyltransferase activity
GO   GO:0000049; F:tRNA binding
GO   GO:0002938; P:tRNA guanine ribose methylation
XX
FT   From: TRMH_THET8 (Q5SM16)
FT   BINDING         122..126
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: G-x-E-[KR]-W
FT   BINDING         99
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [TS]
FT   BINDING         142
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [ILV]
FT   BINDING         151
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: L
XX
Size: 187-267;
Related: None;
Template: Q5SM16; P0AGJ2; Q72GI1; O67577;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/10/13
//