AC   MF_02074;
DC   Protein; auto
TR   HAMAP; MF_02074; -; 1; level=0
XX
Names: Bact_renalase
XX
ID   RNLS
DE   RecName: Full=Renalase;
DE            EC=1.6.3.5;
XX
CC   -!- FUNCTION: Catalyzes the oxidation of the 1,2-dihydro- and 1,6-
CC       dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve
CC       to protect primary metabolism dehydrogenases from inhibition by the
CC       1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+);
CC         Xref=Rhea:RHEA:40395, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88138; EC=1.6.3.5;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+);
CC         Xref=Rhea:RHEA:40399, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88137; EC=1.6.3.5;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+);
CC         Xref=Rhea:RHEA:48000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:58349, ChEBI:CHEBI:88139; EC=1.6.3.5;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+);
CC         Xref=Rhea:RHEA:47996, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:57540, ChEBI:CHEBI:88140; EC=1.6.3.5;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SIMILARITY: Belongs to the bacterial renalase family.
XX
DR   Pfam; PF01593; Amino_oxidase; 1; trigger=no
XX
KW   FAD
KW   Flavoprotein
KW   NAD
KW   NADP
KW   Nucleotide-binding
KW   Oxidoreductase
XX
GO   GO:0050660; F:flavin adenine dinucleotide binding
GO   GO:0050661; F:NADP binding
GO   GO:0051287; F:NAD binding
GO   GO:0050664; F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
XX
FT   From: RNLS_PSE14 (Q48MT7)
FT   BINDING         32..33
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: [DE]-K
FT   BINDING         56..57
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: Q-Y
FT   BINDING         57..61
FT                   /ligand="substrate"
FT   Optional; Condition: Y-F-T-x-R
FT   BINDING         96..98
FT                   /ligand="substrate"
FT   Optional; Condition: S-P-D
FT   BINDING         13
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: [AS]
FT   BINDING         40
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: R
FT   BINDING         128
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: [IV]
FT   BINDING         185
FT                   /ligand="substrate"
FT   Optional; Condition: T
FT   BINDING         302
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: D
FT   BINDING         308
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         309
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Optional; Condition: V
XX
Size: 320-350;
Related: None;
Template: Q48MT7; Q888A4;
Scope:
 Bacteria; Pseudomonadales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//