AC   MF_02076;
DC   Protein; auto
TR   HAMAP; MF_02076; -; 1; level=0
XX
Names: Glu_tRNA_synth_type2
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ID   SYE
DE   RecName: Full=Glutamate--tRNA ligase;
DE            EC=6.1.1.17;
DE   AltName: Full=Glutamyl-tRNA synthetase;
DE            Short=GluRS;
GN   Name=gltX;
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CC   -!- FUNCTION: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-
CC       step reaction: glutamate is first activated by ATP to form Glu-AMP and
CC       then transferred to the acceptor end of tRNA(Glu).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-
CC         glutamyl-tRNA(Glu); Xref=Rhea:RHEA:23540, Rhea:RHEA-COMP:9663,
CC         Rhea:RHEA-COMP:9680, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:78442, ChEBI:CHEBI:78520,
CC         ChEBI:CHEBI:456215; EC=6.1.1.17;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       Glutamate--tRNA ligase type 2 subfamily.
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DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1; trigger=no
DR   Pfam; PF00749; tRNA-synt_1c; 1; trigger=no
DR   Pfam; PF03950; tRNA-synt_1c_C; 1; trigger=no
DR   PRINTS; PR00987; TRNASYNTHGLU; 1; trigger=no
DR   NCBIfam; TIGR00463; gltX_arch; 1; trigger=no
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KW   Aminoacyl-tRNA synthetase
KW   ATP-binding
KW   Cytoplasm
KW   Ligase
KW   Nucleotide-binding
KW   Protein biosynthesis
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GO   GO:0005524; F:ATP binding
GO   GO:0004818; F:glutamate-tRNA ligase activity
GO   GO:0006424; P:glutamyl-tRNA aminoacylation
GO   GO:0005737; C:cytoplasm
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FT   From: SYE_METJA (Q58772)
FT   MOTIF           98..108
FT                   /note="'HIGH' region"
FT   Condition: P-[SNE]-P-x(4)-[HTS]-[LIVM]-G-x
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Size: 530-640;
Related: MF_01428;
Template: P04805; O25360; P27000; Q8DLI5;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: This signature is specific for archaeal and eukaryotic cytoplasmic glutamate--tRNA ligases.
 See MF_00022 for bacterial and eukaryotic mitochondrial glutamate--tRNA ligases.
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# Revision 1.5 2023/06/01
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