AC   MF_02080;
DC   Protein; auto
TR   HAMAP; MF_02080; -; 1; level=0
XX
Names: FtsI_transpept
XX
case not <OC:Neisseria>
ID   FTSI
DE   RecName: Full=Peptidoglycan D,D-transpeptidase FtsI;
DE            EC=3.4.16.4;
DE   AltName: Full=Penicillin-binding protein 3;
DE            Short=PBP-3;
GN   Name=ftsI;
else case <OC:Neisseria>
ID   PBP2
DE   RecName: Full=Probable peptidoglycan D,D-transpeptidase PenA;
DE            EC=3.4.16.4;
DE   AltName: Full=Penicillin-binding protein 2;
DE            Short=PBP-2;
GN   Name=penA;
end case
XX
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall at the
CC       division septum.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
end case
CC   -!- SIMILARITY: Belongs to the transpeptidase family. FtsI subfamily.
XX
DR   Pfam; PF03717; PBP_dimer; 1; trigger=no
DR   Pfam; PF00905; Transpeptidase; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=yes
XX
KW   Carboxypeptidase
KW   Cell cycle
KW   Cell division
KW   Cell inner membrane
KW   Cell membrane
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Hydrolase
KW   Membrane
KW   Peptidoglycan synthesis
KW   Protease
KW   Septation
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity
GO   GO:0043093; P:FtsZ-dependent cytokinesis
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: FTSI_ECOLI (P0AD68)
FT   ACT_SITE        307
FT                   /note="Acyl-ester intermediate"
FT   Condition: S
XX
Size: 520-690;
Related: None;
Template: P0AD68; P08149;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSEAE
Plasmid: None
Comments: Second copy in Pseudomonas aeruginosa (penicillin-binding protein 3 homolog), which has
 probably the same catalytic activity. Does not match FTSI_CAUVN, which seems divergent.
XX
# Revision 1.8 2023/01/26
//