AC   MF_02081;
DC   Protein; auto
TR   HAMAP; MF_02081; -; 1; level=0
XX
Names: MrdA_transpept
XX
ID   MRDA
DE   RecName: Full=Peptidoglycan D,D-transpeptidase MrdA;
DE            EC=3.4.16.4;
DE   AltName: Full=Penicillin-binding protein 2;
DE            Short=PBP-2;
GN   Name=mrdA;
XX
CC   -!- FUNCTION: Catalyzes cross-linking of the peptidoglycan cell wall.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
CC         transpeptidation of peptidyl-alanyl moieties that are N-acyl
CC         substituents of D-alanine.; EC=3.4.16.4;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds one Zn(2+) ion per subunit.;
end case
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
case <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
end case
CC   -!- SIMILARITY: Belongs to the transpeptidase family. MrdA subfamily.
XX
DR   Pfam; PF03717; PBP_dimer; 1; trigger=no
DR   Pfam; PF00905; Transpeptidase; 1; trigger=no
DR   NCBIfam; TIGR03423; pbp2_mrdA; 1; trigger=no
DR   General; Transmembrane; -; 1; trigger=yes
XX
KW   Carboxypeptidase
KW   Cell inner membrane
KW   Cell membrane
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Hydrolase
KW   Membrane
KW   Peptidoglycan synthesis
KW   Protease
KW   Transmembrane
KW   Transmembrane helix
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: MRDA_ECOLI (P0AD65)
FT   ACT_SITE        330
FT                   /note="Acyl-ester intermediate"
FT   Condition: S
FT   From: MRDA_ACIB2 (D0C8Z9)
FT   BINDING         350
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: D
FT   BINDING         365
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: D
FT   BINDING         371
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: H
FT   BINDING         384
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
XX
Size: 580-810;
Related: None;
Template: P0AD65; D0C8Z9;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 9
# Last updated date: 2024-08-14
# Created date: 2016-12-06
//