AC   MF_02082;
DC   Protein; auto
TR   HAMAP; MF_02082; -; 1; level=0
XX
Names: LysZ
XX
ID   LYSZ
case <OC:Sulfolobales>
DE   RecName: Full=[LysW]-aminoadipate/[LysW]-glutamate kinase;
DE            EC=2.7.2.17;
DE            EC=2.7.2.19;
else case <OC:Archaea> and not <OC:Sulfolobales>
DE   RecName: Full=Putative [LysW]-aminoadipate/[LysW]-glutamate kinase;
DE            EC=2.7.2.17;
DE            EC=2.7.2.19;
else case <OC:Deinococcota>
DE   RecName: Full=[LysW]-aminoadipate kinase;
DE            EC=2.7.2.17;
else case <OC:Bacteria> and not <OC:Deinococcota>
DE   RecName: Full=Putative [LysW]-aminoadipate kinase;
DE            EC=2.7.2.17;
end case
GN   Name=lysZ;
XX
case <OC:Archaea>
CC   -!- FUNCTION: Involved in both the arginine and lysine biosynthetic
CC       pathways. Phosphorylates the LysW-bound precursors glutamate (for
CC       arginine biosynthesis), respectively alpha-aminoadipate (for lysine
CC       biosynthesis).
else case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the phosphorylation of LysW-gamma-alpha-
CC       aminoadipate.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[amino-group carrier protein]-C-terminal-N-(1,4-
CC         dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier
CC         protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-
CC         glutamine + ADP; Xref=Rhea:RHEA:41944, Rhea:RHEA-COMP:9694,
CC         Rhea:RHEA-COMP:9712, ChEBI:CHEBI:30616, ChEBI:CHEBI:78499,
CC         ChEBI:CHEBI:78503, ChEBI:CHEBI:456216; EC=2.7.2.17;
case <OC:Archaea>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-
CC         glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-
CC         phospho-L-glutamyl)-L-glutamate + ADP; Xref=Rhea:RHEA:52632,
CC         Rhea:RHEA-COMP:13311, Rhea:RHEA-COMP:13313, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:136714, ChEBI:CHEBI:136717, ChEBI:CHEBI:456216;
CC         EC=2.7.2.19;
end case
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.
case <OC:Archaea>
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the acetylglutamate kinase family. LysZ
CC       subfamily.
XX
DR   Pfam; PF00696; AA_kinase; 1; trigger=no
DR   PRINTS; PR00474; GLU5KINASE; 1; trigger=no
DR   NCBIfam; TIGR00761; argB; 1; trigger=no
DR   PIRSF; PIRSF000728; NAGK; 1; trigger=no
XX
KW   Amino-acid biosynthesis
case <OC:Archaea>
KW   Arginine biosynthesis
end case
KW   ATP-binding
KW   Cytoplasm
KW   Kinase
KW   Lysine biosynthesis
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0016301; F:kinase activity
case <OC:Archaea>
GO   GO:0042450; P:arginine biosynthetic process via ornithine
end case
GO   GO:0019878; P:lysine biosynthetic process via aminoadipic acid
GO   GO:0005737; C:cytoplasm
XX
FT   From: LYSZ_SULAC (Q4JAQ2)
FT   BINDING         35..36
FT                   /ligand="substrate"
FT   Condition: G-G
FT   BINDING         62
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         166
FT                   /ligand="substrate"
FT   Condition: N
FT   SITE            5
FT                   /note="Transition state stabilizer"
FT   Condition: K
FT   SITE            223
FT                   /note="Transition state stabilizer"
FT   Condition: K
XX
Size: 240-330;
Related: None;
Template: Q4JAQ2; Q980X0; O50147;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/06/01
//