AC   MF_02083;
DC   Protein; auto
TR   HAMAP; MF_02083; -; 1; level=0
XX
Names: LysY
XX
ID   LYSY
case <OC:Sulfolobales>
DE   RecName: Full=[LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
DE            EC=1.2.1.103;
DE            EC=1.2.1.106;
else case <OC:Archaea> and not <OC:Sulfolobales>
DE   RecName: Full=Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase;
DE            EC=1.2.1.103;
DE            EC=1.2.1.106;
else case <OC:Deinococcota>
DE   RecName: Full=[LysW]-L-2-aminoadipate 6-phosphate reductase;
DE            EC=1.2.1.103;
else case <OC:Chloroflexota>
DE   RecName: Full=Putative [LysW]-L-2-aminoadipate 6-phosphate reductase;
DE            EC=1.2.1.103;
end case
GN   Name=lysY;
XX
case <OC:Archaea>
CC   -!- FUNCTION: Involved in both the arginine and lysine biosynthetic
CC       pathways.
else case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of [LysW]-
CC       aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-
CC         oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group
CC         carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-
CC         yl)-L-glutamine + H(+) + NADPH; Xref=Rhea:RHEA:41948, Rhea:RHEA-
CC         COMP:9712, Rhea:RHEA-COMP:9714, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78499,
CC         ChEBI:CHEBI:78501; EC=1.2.1.103;
case <OC:Archaea>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-
CC         semialdehyde)-L-glutamate + NADP(+) + phosphate = [amino-group
CC         carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate
CC         + H(+) + NADPH; Xref=Rhea:RHEA:52668, Rhea:RHEA-COMP:13313,
CC         Rhea:RHEA-COMP:13327, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:136717,
CC         ChEBI:CHEBI:136761; EC=1.2.1.106
end case
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.
case <OC:Archaea>
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 1
CC       subfamily. LysY sub-subfamily.
XX
DR   PROSITE; PS01224; ARGC; 1; trigger=no
DR   Pfam; PF01118; Semialdhyde_dh; 1; trigger=no
DR   Pfam; PF02774; Semialdhyde_dhC; 1; trigger=no
DR   NCBIfam; TIGR01850; argC; 1; trigger=no
XX
KW   Amino-acid biosynthesis
case <OC:Archaea>
KW   Arginine biosynthesis
end case
KW   Cytoplasm
KW   Lysine biosynthesis
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
case <OC:Archaea>
GO   GO:0042450; P:arginine biosynthetic process via ornithine
end case
GO   GO:0019878; P:lysine biosynthetic process via aminoadipic acid
GO   GO:0005737; C:cytoplasm
XX
FT   From: LYSY_THET2 (O50146)
FT   BINDING         12..15
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [ST]-G-x-[VITA]
FT   BINDING         36..38
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: S-[RK]-[RK]
FT   ACT_SITE        148
FT   Condition: C
FT   BINDING         312
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Condition: N
XX
Size: 330-385;
Related: MF_00150;
Template: O50146; Q4JAQ3; Q980X1;
Scope:
 Archaea
 Bacteria; Chloroflexota
 Bacteria; Deinococcota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: MF_02083 is a subfamily of MF_00150.
XX
# Revision 1.11 2023/06/01
//