AC   MF_02084;
DC   Protein; auto
TR   HAMAP; MF_02084; -; 1; level=0
XX
Names: LysJ_aminotrans_3
XX
ID   LYSJ
case <OC:Sulfolobales>
DE   RecName: Full=[LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase;
DE            EC=2.6.1.118;
DE            EC=2.6.1.124;
else case <OC:Archaea> and not <OC:Sulfolobales>
DE   RecName: Full=Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase;
DE            EC=2.6.1.118;
DE            EC=2.6.1.124;
else case <OC:Deinococcota>
DE   RecName: Full=[LysW]-aminoadipate semialdehyde transaminase;
DE            EC=2.6.1.118;
else case <OC:Chloroflexota>
DE   RecName: Full=Putative [LysW]-aminoadipate semialdehyde transaminase;
DE            EC=2.6.1.118;
end case
GN   Name=lysJ;
XX
case <OC:Archaea>
CC   -!- FUNCTION: Involved in both the arginine and lysine biosynthetic
CC       pathways.
else case <OC:Bacteria>
CC   -!- FUNCTION: Catalyzes the transfer of the amino group of L-glutamate to
CC       [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + [amino-group carrier protein]-C-terminal-
CC         gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-
CC         terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate;
CC         Xref=Rhea:RHEA:41952, Rhea:RHEA-COMP:9714, Rhea:RHEA-COMP:9715,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:78501,
CC         ChEBI:CHEBI:78526; EC=2.6.1.118;
case <OC:Archaea>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + [amino-group carrier protein]-C-terminal-
CC         gamma-(L-ornithyl)-L-glutamate = [amino-group carrier protein]-C-
CC         terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + L-glutamate;
CC         Xref=Rhea:RHEA:52672, Rhea:RHEA-COMP:13327, Rhea:RHEA-COMP:13328,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:136761,
CC         ChEBI:CHEBI:136763; EC=2.6.1.124;
end case
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC       Note=Binds 1 pyridoxal phosphate per subunit
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5.
case <OC:Archaea>
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
end case
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. LysJ subfamily.
XX
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1; trigger=no
DR   Pfam; PF00202; Aminotran_3; 1; trigger=no
DR   NCBIfam; TIGR00707; argD; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Aminotransferase
case <OC:Archaea>
KW   Arginine biosynthesis
end case
KW   Cytoplasm
KW   Lysine biosynthesis
KW   Pyridoxal phosphate
KW   Transferase
XX
GO   GO:0008483; F:transaminase activity
case <OC:Archaea>
GO   GO:0042450; P:arginine biosynthetic process via ornithine
end case
GO   GO:0019878; P:lysine biosynthetic process via aminoadipic acid
GO   GO:0005737; C:cytoplasm
XX
FT   From: LYSJ_THET8 (Q5SHH5)
FT   BINDING         113..114
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT   Optional; Condition: G-[TA]
FT   BINDING         225..228
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT   Optional; Condition: D-E-[IV]-Q
FT   BINDING         140
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT   Optional; Condition: F
FT   BINDING         143
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         282
FT                   /ligand="substrate"
FT   Optional; Condition: [ST]
FT   BINDING         283
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT   Optional; Condition: T
FT   MOD_RES         254
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 360-450;
Related: None;
Template: Q4JAP8; Q93R93; Q5SHH5;
Scope:
 Archaea
 Bacteria; Chloroflexota
 Bacteria; Deinococcota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2023/06/01
//